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OCR: st Hypopituitarism also occurs and this mo tion. Later frequently affects gonadotrophin produc hyroidism in the development of the disease, hypo ur due to and adrenocortical insufficiency may occ TSH) and decreased thyroid stimulating hormone eserves. adrenocorticotrophic hormone (ACTH) on the Hypopituitarism may be due to pressure e to stalk by the tumour but is more often du ary tissue pressure of the tumour on normal pituit from in the fossa. Diabetes insipidus, resulting upward extension of the tumour into th hypothalamus is exceedingly rare.